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麻醉監測||腦(nǎo)電(diàn)圖與β&意識


以下(xià)文(wén)章(zhāng)來(lái)源于小(xiǎo)♥'麻哥(gē)的(de)日(rì)常 ,作(zuò)者兩隻小(xiǎo)綿羊



麻醉監測||腦(nǎo)電(diàn)圖與意識(圖1)


摘要(yào)譯文(wén)(供參考)


靜(jìng)息狀态腦(nǎo)電(diàn)圖的(d✘<<§e)臨界性預測麻醉過程中的(de)擾動複雜(zá)性和(hé)意識≤∞ 水(shuǐ)平


意識已被提出由處于臨界狀态的(de)電(diàn)生(shēng)理(lǐ<β)學模式支持,這(zhè)是(shì)一(yī)種表現(xiàn)→∏出自(zì)适應計(jì)算(suàn)特性、最大(≠β‌₽dà)複雜(zá)模式和(hé)對(duì)擾動的(de)發散敏感性π 的(de)動态機(jī)制(zhì)。


在此,我們研究了(le)接受丙泊酚、氙氣或氯胺酮全身(shēn)麻醉的(de)健康受試者靜(jìng)息狀βΩ®态腦(nǎo)電(diàn)圖的(de)動态特性


然後,我們研究了(le)這(zhè)些(xiē)動态特性與擾動複雜≠≤∞(zá)性指數(shù)(PCI)的(de)關系,該指數(shù‍​₽ )在獨立于行(xíng)為(wèi)的(de)✔↔ 意識檢測中顯示出顯著的(de)高(gāo)靈敏←₩×δ度。


所有(yǒu)參與者在麻醉下(xià)都(dōu)沒有α"₽(yǒu)反應,而意識隻有(yǒu)在氯胺酮麻醉(以∞÷π•生(shēng)動的(de)夢的(de)形式)時(shí)才能(n& éng)保持,這(zhè)使得(de)無反應和(hé)無意識之間(ji♥♣∞λān)的(de)實驗分(fēn)離(lí)成為(wèi)可(kě)能(néng​♣♥)。


我們估計(jì)(i)雪(xuě)崩臨界,(ii)混亂,和(hé)&₽♥(iii)臨界相(xiàng)關的(de)測量,發現(xiàn)無意識狀态的®♦(de)特征是(shì)遠(yuǎn)離(lí)活動傳播的(de)邊緣和(¥♥₽hé)混亂的(de)邊緣。


然後我們能(néng)夠預測個(gè)體(tǐ)受試者的(de)PCI$ ≤(即PCI最大(dà)值我們的(de)結果建立♥σ₽≈了(le)PCI和(hé)臨界性之間(jiān)₽♦±的(de)緊密聯系,并為(wèi)臨界性在δ¶¶意識出現(xiàn)中的(de)作(zuò)用(yòng) λ★提供了(le)進一(yī)步的(de)證據。


原文(wén)摘要(yào)


Criticality of resting-state EEG pred→♥icts perturbational co •♣εmplexity and level of conscioγ₽ usness during anesthesia


Consciousness has been proposγα&±ed to be supported by electro ​β$physiological patterns poised at critic₽←ality, a dynamical regime'∏π≤ which exhibits adapt π≠ive computational properti₽₽γ​es, maximally complex patter©¶  ns and divergent sensitivity βε✔ to perturbation. Here, we investigateφ£d dynamical properties of the restin♥€g-state electroencephalogram of♣→ healthy subjects unde ♣¶rgoing general anesthesia with propofoφ♥>∑l, xenon or ketamine. We thשen studied the relation of thesφ©δe dynamic properties wit€←↑h the perturbational complexity index (¥±PCI), which has shown remark ε≠<ably high sensitivity in detecting≤∏λ♣ consciousness indepφ↓endent of behavior. All parti₽♥cipants were unresponsive unδ© ₩der anesthesia, while consciousness←$ was retained only duri÷₩∞£ng ketamine anesthesia (inσ₽₹ the form of vivid dreams)., en ‌abling an experimental dissociation™≈ between unresponsiveness and unconscio☆βusness. We estimated (i) avα★alanche criticality, (' ∑ii) chaoticity, and (iii) c₩&riticality-related measures, ↕÷‌and found that states of unconsciousn♦∏ess were characterized by a distancin≤π₽g from both the edge of ↓↓§activity propagation and ©₹the edge of chaos. We were then able  >δto predict individual s¶✘Ω‌ubjects' PCI (i.e., PC±<↓Imax) with a mean absoluteγε¶' error below 7%. Our results§Ω establish a firm link between tδ"®♠he PCI and criticality and φ&provide further evide÷σε↕nce for the role of criticality in≈®↕ the emergence of consc♦σ∑iousness.








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